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Title: Modified β-lactamases and uses thereof
Authors: Wong, Kwok-yin
Leung, Thomas Y. C.
Chan, Pak-ho
Subjects: β-lactamases
Issue Date: 29-Jan-2008
Source: US Patent 7,323,303 B2. Washington, DC: US Patent and Trademark Office, 2008.
Abstract: A tool that can screen bacteria for β-lactamases against a panel of various antibiotics is desirable. A biosensor incorporating an indicator molecule into β-lactamases may achieve this purpose, but it requires that the attached indicator molecule must not impair the binding affinity of the protein to a great extent to provide a higher sensitivity. A modified β-lactamases with a residue on the Ω-loop or outside the Ω-loop but close to the active site of β-lactamase being replaced by a reactive residue is developed in this invention.
Rights: Assignee: The Hong Kong Polytechnic University.
Type: Patent
Appears in Collections:Patents of PolyU
ABCT Patents

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