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Title: Consumption of dried fruit of Crataegus pinnatifida (hawthorn) suppresses high-cholesterol diet-induced hypercholesterolemia in rats
Authors: Kwok, Ching-yee
Wong, Candy Ngai-yan
Yau, Mabel
Yu, Peter H.
Au, Alice Lai Shan
Poon, Christina Chui-Wa
Seto, Sai-Wang
Lam, Tsz-Yan
Kwan, Yiu-Wa
Chan, Shun-wan
Subjects: Cholesterol
Crataegus pinnatifida
Dietary supplement
High-fat diet
Issue Date: Jul-2010
Publisher: Elsevier
Source: Journal of functional foods, July 2010, v. 2, no.3, p. 179-186.
Abstract: The hypocholesterolemic and atheroscleroprotective potentials of dietary consumption of hawthorn (dried fruit of Crataegus pinnatifida, Shan Zha) were investigated by monitoring plasma lipid profiles and aortic relaxation in Sprague–Dawley rats fed with either normal diet, high-cholesterol diet (HCD) or HCD supplemented with hawthorn powder (2%, w/w) (4 weeks). In HCD-fed rats, an increased plasma total cholesterol and LDL-cholesterol with a decreased HDL-cholesterol was observed, and consumption of hawthorn markedly suppressed the elevated total cholesterol and LDL-lipoprotein levels plus an increased HDL-cholesterol level. The blunted acetylcholine-induced, endothelium-dependent relaxation of isolated aortas of HCD-fed rats was improved by hawthorn. The development of fatty liver, an increased nitric oxide synthase (NOS) activity and an elevated oxidative stress (as estimated by the attenuated levels of anti-oxidant enzymes) associated with HCD were attenuated by hawthorn. Thus, the results demonstrated that hawthorn consumption provides overall beneficial effects on reversing HCD associated detrimental changes.
Rights: Journal of Functional Foods © 2010 Elsevier Ltd. The journal web site is located at
Type: Journal/Magazine Article
DOI: 10.1016/j.jff.2010.04.006
ISSN: 1756-4646
Appears in Collections:ABCT Journal/Magazine Articles

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