PolyU IR
 

PolyU Institutional Repository >
Health Technology and Informatics >
HTI Journal/Magazine Articles >

Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/2320

Title: High resolution ultrasound elastomicroscopy imaging of soft tissues : system development and feasibility
Authors: Zheng, Yong-Ping
Bridal, L.
Shi, Jun
Saied, A.
Lu, Min-Hua
Jaffre, B.
Mak, Arthur F. T.
Laugier, P.
Subjects: Instrumentation and measurement
Biological physics
Medical physics
Issue Date: 7-Sep-2004
Publisher: IOP Publishing
Citation: Physics in medicine and biology, 7 Sept. 2004, v. 49, no. 17, p. 3925-3938.
Abstract: Research in elasticity imaging typically relies on 1–10 MHz ultrasound. Elasticity imaging at these frequencies can provide strain maps with a resolution in the order of millimetres, but this is not sufficient for applications to skin, articular cartilage or other fine structures. We developed a prototype high resolution elastomicroscopy system consisting of a 50 MHz ultrasound backscatter microscope system and a calibrated compression device using a load cell to measure the pressure applied to the specimen, which was installed between a rigidly fixed face-plate and a specimen platform. Radiofrequency data were acquired in a B-scan format (10 mm wide × 3 mm deep) in specimens of mouse skin and bovine patellar cartilage. The scanning resolution along the B-scan plane direction was 50 µm, and the ultrasound signals were digitized at 500 MHz to achieve a sensitivity better than 1 µm for the axial displacement measurement. Because of elevated attenuation of ultrasound at high frequencies, special consideration was necessary to design a face-plate permitting efficient ultrasound transmission into the specimen and relative uniformity of the compression. Best results were obtained using a thin plastic film to cover a specially shaped slit in the face-plate. Local tissue strain maps were constructed by applying a cross-correlation tracking method to signals obtained at the same site at different compression levels. The speed of sound in the tissue specimen (1589.8 ± 7.8 m s‾¹ for cartilage and 1532.4 ± 4.4 m s‾¹ for skin) was simultaneously measured during the compression test. Preliminary results demonstrated that this ultrasound elastomicroscopy technique was able to map deformations of the skin and articular cartilage specimens to high resolution, in the order of 50 µm. This system can also be potentially used for the assessment of other biological tissues, bioengineered tissues or biomaterials with fine structures.
Description: DOI: 10.1088/0031-9155/49/17/007
Rights: © 2004 Institute of Physics and Engineering in Medicine. The online abstract of the journal is located at: http://iopscience.iop.org/0031-9155/53/10/006/
Type: Journal/Magazine Article
URI: http://hdl.handle.net/10397/2320
ISSN: 0031-9155
Appears in Collections:HTI Journal/Magazine Articles

Files in This Item:

File Description SizeFormat
Zheng et al PMB 2004 Ultrasound electromicroscopy -final version.pdfPre-published version997.15 kBAdobe PDFView/Open
Locate publisher version via PolyU eLinks



Facebook Facebook del.icio.us del.icio.us LinkedIn LinkedIn


All items in the PolyU Institutional Repository are protected by copyright, with all rights reserved, unless otherwise indicated.
No item in the PolyU IR may be reproduced for commercial or resale purposes.

 

© Pao Yue-kong Library, The Hong Kong Polytechnic University, Hung Hom, Kowloon, Hong Kong
Powered by DSpace (Version 1.5.2)  © MIT and HP
Feedback | Privacy Policy Statement | Copyright & Restrictions - Feedback