Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/1873
Title: Graph-based Mumford-Shah segmentation of dynamic PET with application to input function estimation
Authors: Parker, Brian J.
Feng, D. David
Subjects: Brain modeling
Covariance analysis
Graph theory
Image segmentation
Mumford–Shah
Pattern recognition
Positron emission tomography
Issue Date: Feb-2005
Publisher: IEEE
Source: IEEE transactions on nuclear science, Feb. 2005, v. 52, no. 1, p. 79-89.
Abstract: A graph-theoretic three-dimensional (3-D) segmentation algorithm based on Mumford-Shah energy minimization is applied to the segmentation of brain [sup 18]F-fluoro-deoxyglucose (FDG) dynamic positron emission tomography data for the automated extraction of tissues with distinct time activity curves (TACs), and, in particular, extraction of the internal carotid arteries and venous sinuses for the noninvasive estimation of the input arterial TAC. Preprocessing by principal component analysis (PCA) and a Mahalanobis distance metric provide segmentation based on distinct TAC shape rather than simply activity levels. Evaluations on simulation and clinical FDG brain positron emission tomography (PET) studies demonstrate that differing tissue types can be accurately demarcated with superior performance to k-means clustering approaches, and, in particular, the internal carotids and venous sinuses can be robustly segmented in clinical brain dynamic PET datasets, allowing for the fully automatic noninvasive estimation of the arterial input curve.
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Type: Journal/Magazine Article
URI: http://hdl.handle.net/10397/1873
DOI: 10.1109/TNS.2004.843133
ISSN: 0018-9499
Appears in Collections:EIE Journal/Magazine Articles

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