Please use this identifier to cite or link to this item: http://hdl.handle.net/10397/1863
Title: Fast and reliable estimation of multiple parametric images using an integrated method for dynamic SPECT
Authors: Wen, Lingfeng
Eberl, Stefan
Feng, D. David
Cai, Weidong
Bai, Jing
Subjects: Clustering methods
Parameter estimation
Sampling methods
Single photon emission computed tomography (SPECT)
Issue Date: Feb-2007
Publisher: IEEE
Source: IEEE transactions on medical imaging, Feb. 2007, v. 26, no. 2, p. 179-189.
Abstract: Dynamic single photon emission computed tomography (SPECT) has demonstrated the potential to quantitatively estimate physiological parameters in the brain and the heart. The generalized linear least square (GLLS) method is a well-established method for solving linear compartment models with fast computational speed. However, the high level of noise intrinsic in the SPECT data leads to reliability and instability problems of GLLS for generating parametric images. An integrated method is proposed to restrict the noise in both the temporal and spatial domains to estimate multiple parametric images for dynamic SPECT. This method comprises three steps which are optimum image sampling schedule in the projection space, cluster analysis applied postreconstruction and parametric image generation with GLLS. The simulation and experimental studies for the neuronal nicotine acetylcholine receptor tracer of 5-[¹ ² ³ I]-iodo-A-85380 were employed to evaluate the performance of the proposed method. The results of influx rate of K₁ and volume of distribution of V[sub d]demonstrated that the integrated method was successful in generating low noise parametric images for high noise SPECT data without enhancing the partial volume effect. Furthermore, the integrated method is computationally efficient for potential clinical applications.
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Type: Journal/Magazine Article
URI: http://hdl.handle.net/10397/1863
DOI: 10.1109/TMI.2006.889708
ISSN: 0278-0062
Appears in Collections:EIE Journal/Magazine Articles

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